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Issue
Korean Journal of Chemical Engineering,
Vol.28, No.12, 2316-2318, 2011
Evaluation of the reducing power effect on the enantioselective synthesis of methyl (R)-2-chloromandelate using Saccharomyces cerevisiae
Jeong M, Yoo IK, Han MJ, Hong SH
The effect of the reducing power on the reduction of methyl-2-chlorobenzoylformate was evaluated by using carbon substrates with different reducing powers. Glucose, sorbitol, and gluconate regenerated 2, 3, and 1 NAD(P)H during its conversion to pyruvate, respectively. When sorbitol was used as the carbon substrate, complete conversion was achieved in 8 h while it took 12 h and 19 h when glucose and gluconate were used, respectively. The enantiomeric excess (ee) value was 96.7% when sorbitol was used.
Keywords: Asymmetric Reduction; Reducing Power; Methyl (R)-2-Chloromandelate; Saccharomyces cerevisiae
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