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Issue
Korean Journal of Chemical Engineering,
Vol.28, No.4, 1070-1073, 2011
Identification of depigmenting components from Nigella glandulifera Freyn
Hoang DN, Lee JE, Kim EK
To develop a novel skin depigmenting agent from natural sources, the inhibition of melanogenesis by Chinese plants, N. glandulifrea, was evaluated. The methanol extract of this plant showed significantly down-regulated melanin synthesis in a dose-dependent manner at a non-toxic concentration in cultured B16F10 mouse melanoma cells. This extract was further fractionated by using solvent-solvent partition and silica open column chromatography to identify the active components. From GC-MS data, oleic acid methyl ester was found as one of the depigmenting agents. In conclusion, we suggest that this fraction may be a safe and effective depigmentation agent.
Keywords: Melanogenesis; Depigmenting; Identification
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