Ca-Alginate-Gel is one of the most widely used carriers for cell entrapment. Since gel formation can take place under mild conditions, entrapment in this matrix is very suitable for immobillzation of viable cells and it has found most extensive application. Despite of the extended use there have been no kinetic data related to gel formation of alginate with calcium ion. In the present work the kinetic study was accomplished to more fully elucidate the transient structure transformations involved in the gel formation using shrinking-core model. The proposed kinetic model may be successfully extended to account for the transient behavior and complete gelling time as well as some useful information of the gelling conditions in the process of Ca-Alginate-Gel.