Print: | ISSN 0256-1115 |
Online: | ISSN 1975-7220 |
Korean Journal of Chemical Engineering,
Vol.27, No.1, 231-234, 2010 Simulated moving-bed for separation of mandelic acid racemic mixtures
Two enantiomers that constitute a racemate have different activities when employed as pharmaceuticals. Consequently, the pharmaceutical industry has been forced to market pure enantiomers instead of the racemic mixture. Simulated moving bed (SMB) is a chromatographic process that operates continuously without losing the enantiomeric purity of outlet streams from SMB. The present work describes the enantioseparation of mandelic acid in a labscale SMB unit. Chiral stationary phase was made by packing Kromasil TBB (O,O'-bis(4-tert-buylbenzoyl) -N,N'-diallyl-L-tartar diamid ) gel into empty columns. The outlet streams were sampled and analyzed by an analytical HPLC. Analysis indicated that purity values range from 82% to 94% according to the change of extract stream flow rate.
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