A multi-fluid nonrandom lattice fluid model with no temperature dependence of close packed volumes of a mer, segment numbers and energy parameters of pure systems and its consistent method for phase equilibrium calculation were presented in the previous paper. In this work, the model was extended to mixtures by using consistent method for phase equilibrium calculation with fugacity coefficients derived from the present equation of state and it was applied to vapor-liquid equilibrium. We consistently tested the present model on 17 phase equilibrium data sets of vapor-liquid equilibria and compared it with the MF-NLF model and the SAFT model. The present model (3 pure parameters for pure component and one binary interaction parameter) showed better results for most systems than the MF-NLF model (6 adjustable pure parameters and one binary interaction parameter) and the SAFT model (3 pure parameters and one binary interaction parameter).