The Ministry of the Environment in Korea supports investigation of various substances that are potential contaminants of the environment and could cause adverse effects on the environment and/or human health and to list Priority Substances (PSL). The present study for PSL is aimed at estimating the new PSL for industrial areas or assessing the risk of refining processes for selecting priority substances in order to obtain better criteria of quality data. The present study lists 81 major priority substances among 106 candidate substances and scores with weight factors to CHEMS-1 based on amounts of materials in circulation and emissions levels. Of the 81 chemicals, 80% are classified as carcinogens, potentially causing acute oral toxicity among those within the 1st grade of data quality criteria for materials. For data quality criteria of items, BOD or hydrolysis half-life is the lowest 40% and acute oral toxicity is the highest 90%.