In order to achieve a comprehensive understanding of the performance of the heteropoly compound (HPC) absorbent systems for H2S removal developed before this study, a comparable study was made concerning the desulfurization characteristics, sulfur loading capacity (SLC) and desulfurization product composition, taking Fe-EDTA system as a standard. The desulfurization effect of HPC multicomponent absorbent system can be greater than that of Fe-EDTA system during long time of operation; the regeneration effects of HPC and Fe-EDTA system are similar. The SLC of single HPC is almost the same as that of the Fe-EDTA system, and the multicomponent system of HPC has SLC which is 12.93% higher. Furthermore, the desulfurization product from HPC system contains sulfur mainly, which is superior to that from Fe-EDTA system. Hence, HPC absorbent system developed would be of promising application value.