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Issue
Korean Journal of Chemical Engineering,
Vol.18, No.4, 479-485, 2001
Evaluation of Shear-Induced Particle Diffusivity in Red Cell Ghosts Suspensions
Cha W, Beissinger RL
The shear-induced particle diffusivity in the red blood cell suspensions was evaluated based on the flow model and experimental results in a rectangular flow chamber. The effective diffusivity (D(e)) of solute in the particle suspensions is equal to the stationary diffusivity (D(s)) of the solute plus the shear-induced particle diffusivity (D(p)). The effective diffusivity (D(e)) of bovine serum albumin (BSA) in the red blood cell (RBC) ghost suspensions was determined under diffusion-limited conditions using a total internal reflection fluorescence (TIRF) method as a function of suspended RBC ghost volume fractions (0.05-0.7) and shear rates (200-1,000 s(-1)). The stationary diffusivity (D(s)) of BSA in RBC ghost suspensions was calculated by Meredith and Tobias model. Therefore the shear-induced particle diffusivity undergoing laminar shear flow can be evaluated. The shear-induced RBC ghost diffusivity was ranged from 0.35×10(-7) to 21.2×10(-7) cm(2)/s and it increased with increasing shear rate. Also the shear-induced RBC ghost diffusivity increased as a particle volume fraction increased as well, up to a particle volume fraction of 0.45. However, for RBC ghost volume fractions above 0.45, the shear-induced particle diffusivity decreased with increasing particle volume fraction. The shear-induced particle diffusivity in RBC ghost suspensions is a function of a particle Peclet number (or shear rate) and particle volume fractions. The dimensionless particle diffusivity (D(p)/a(2)g) was investigated as a function of particle volume fraction and these results are in good agreement with the literature values.
Keywords: Shear-Induced Particle Diffusivity; Effective Diffusivity; Suspension; Red Blood Cell Ghost; Particle Motion
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[Cited By]
  1. Kim C, Korean Journal of Chemical Engineering, 21(1), 27, 2004
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