| Issue |
Korean Journal of Chemical Engineering,
Vol.17, No.6, 638-642, 2000
Vol.17, No.6, 638-642, 2000
Salt-Induced Protein Precipitation in Aqueous Solution: The Effect of Pre-Aggregation
A molecular-thermodynamic model is developed for the salt-induced protein precipitation The protein molecules interact through four intermolecular potentials. An equation of state is derived based on the statistical mechanical perturbation theory with the modified Chiew's equation as the reference system and a perturbation based on the protein-protein interaction potential of mean force. The equation of state provides an expression for the chemical potential of the protein and determines liquid-liquid equilibria. The precipitation behaviors are studied by calculating the partition coefficient with changing conditions such as ionic strength, protein and salt size, and the degree of pre-aggregation effect. The reasonable pre-aggregation effects are determined by comparing the proposed model with experimental data.
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[Cited By]
참고문헌정보(참고문헌, 인용문헌)는 화학공학소재연구정보센터에 의해 제공되고 있습니다.