Organic pollutant removal can be realized via electrochemical degradation, and anodic oxidation plays an important role in the degradation process. However, the degradation process is hindered by low removal efficiency and reusability. In this study, a PbO2 electrode and a Mn-doped PbO2 (Mn-PbO2) electrode were prepared via electrodeposition. Different from the traditional method of increasing the oxygen evolution potential (OEP) of PbO2 electrode, such as introducing Ce, Bi, and La in PbO2 electrode, introducing Mn in PbO2 electrode promoted the generation of strong oxidant MnO4  under electrolytic conditions to remove organic pollutants. The Mn-PbO2 electrode was used for anthracene (ANT) degradation and the results showed that an ANT removal efficiency of 91.28% was achieved in 120 min under the most suitable operational variables, namely, a Na2SO4 concentration of 0.1M, initial pH of 7, and current density of 20 mA/cm2. In addition, the ANT degradation mechanism was analyzed. Given that the Mn-PbO2 electrode exhibited better removal efficiency in the wide pH range and remarkable degradation efficiency compared with the PbO2 electrode, the Mn-PbO2 electrode has practical application prospects for organic pollutant degradation.