Hybrid grafted nano cellulose was prepared in the existence of glycidyl methacrylate and functionalized by an amine group. Amine-modified grafted nano cellulose and its adsorption behavior were studied using a batch technology to an aqueous uranium solution, where the equilibrium and maximum uptake capacities were carried out at room temperature within 1 h at pH 5. Characterization of the modified cellulose occurred utilizing FTIR, TGA, and TEM. Whereas theoretical characterization was applied to demonstrate the process of multicomponent mass transfer into the new functional grafted nano cellulose sorbent by MATLAB using several mathematical models like Freundlich, Langmuir, Redlich-Peterson, and Brunauer-Emmett-Teller for describing the equilibrium data of the uranium (VI) ions adsorption process. As the bridge between physics and chemistry, the thermodynamic parameters and kinetic parameters were calculated to describe the nature of the sorption process and the type of interaction, respectively. The reaction was followed a pseudo-second order (two parallel pseudo-first orders) model by relatively fast kinetics mixed between chemical and solid diffusion-controlled reactions manner. Finally, uranium (VI) ions sorption process exhibited an endothermic and spontaneous process in (2D) and (3D).