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Issue
Korean Journal of Chemical Engineering,
Vol.39, No.2, 227-240, 2022
Emerging strategies for biomaterial-assisted cancer immunotherapy
Joo KI
Among many treatment options to prevent cancer progression, cancer immunotherapy has become a powerful clinical strategy due to its favorable clinical outcomes. The number of clinical trials in immune checkpoint blockad (ICB) therapy and chimeric antigen receptor (CAR)-T cell therapy has been remarkably increasing in recent years. However, the currently available options for these treatments pose significant challenges related to immune-related adverse effects and limited therapeutic efficacy. Excellent delivery technologies by leveraging biomaterials to mitigate these limitations could potentially advance current cancer immunotherapies for a wide range of applications. In this review, we analyze various strategies of biomaterial-assisted cancer immunotherapy for localized, targeted, and combined treatments and then summarize the promises and challenges for integrating biomaterial-based delivery technologies into cancer immunotherapy.
Keywords: Cancer Immunotherapy; Biomaterials; Localized Delivery; Immuno-engineering; Combination Therapy
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