The present study employs an unexplored, one-step route for remediation of ciprofloxacin, an emerging contaminant, using hydrophobically modified ceramic membranes. Hydrophobic interaction between the membrane and the target contaminant, i.e., ciprofloxacin, is the governing factor responsible for its removal. The hydrophilic surface of hollow, single channel, macroporous clay-alumina membranes was made hydrophobic using cross-linked polydimethylsiloxane. The influencing parameters--concentration of polymer, cross-linking agent, catalyst and coating time--were optimized by Taguchi analysis to yield a membrane with enhanced ciprofloxacin rejection and high permeate flux. The synthesized membrane was characterized for its contact angle, clean water permeability, degree of swelling, degree of cross-linking, X-Ray diffraction, atomic fluorescence microscopy, field emission scanning electron microscopy. Effect of various operating parameters--cross flow velocity, transmembrane pressure, filtration time, solution pH--was investigated upon removal of ciprofloxacin in cross flow membrane filtration. Maximum rejection of 99.3% was obtained by the hydrophobic membrane having contact angle of 138.5 ° for 5mg/L feed solution. The stability of the membrane was judged in terms of change in ciprofloxacin rejection upon filtration for five consecutive cycles, each cycle being 180min. The developed PDMS/ceramic composite membranes could have great prospect for longterm application in removal of emerging contaminants from water.