Guar gum is an effective agent for use as a natural adhesive ingredient that can be used to replace the hazardous ingredients of spirit gum. This study describes the possibility of using guar gum as a renewable substituent for cosmetic adhesive. An adhesive base and cosmetic adhesive containing guar gum were prepared by a two-step process. The samples were tested for safety (cell toxicity test and patch test), stability (centrifugation, cycling and viscosity), and effectiveness (tensile strength). The results from the MTT assay show that the growth activity of human fibroblast skin cells was over 89% in all concentrations of cosmetic adhesive containing guar gum. In addition, no special skin reactions were reported in the patch test prepared adhesive containing guar gum. Moreover, the stability test demonstrated proper stability of all adhesive samples: the composition stability, heat stability, and viscosity of the adhesive samples maintained stable conditions. The efficacy test confirmed the superiority of the guar gum adhesive samples over spirit gum concerning the tensile strength. This study demonstrated that guar gum may be a viable replacement for synthetic rosins and also as a substituent in cosmetic.