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Issue
Korean Journal of Chemical Engineering,
Vol.33, No.9, 2738-2746, 2016
Physical characteristics and in vitro skin permeation of elastic liposomes loaded with caffeic acid-hydroxypropyl-β-cyclodextrin
Im NR, Kim KM, Young SJ, Park SN
We developed a drug-in-cyclodextrin-in-elastic liposomes (DCEL) system to enhance transdermal delivery of caffeic acid (CA). Hydroxypropyl-β-cyclodextrin (HP-β-CD) was used as a hydrophilic CD. Elastic liposomes (EL) contained polyethylene glycol-free Tego® care 450 as an edge activator. Properties of the CA-HP-β-CD inclusion complex loaded in EL (CD-EL) as DCEL system were compared to characteristics of conventional liposomes (CL), EL, and CD-CL. Particle size, deformability, entrapment efficiency (EE%), stability, and vesicle morphology were characterized in liposome preparations. In addition, in vitro release and skin permeation were analyzed. We found that including Tego® care 450 reduced vesicle size and increased membrane deformability. The addition of HP-β-CD enhanced CA EE% of liposomes almost 1.6-fold that of liposomes without HP-β-CD. Moreover, CD-EL complex showed better controlled release profiles and higher skin permeability than CL and EL. We propose that the DCEL system can be a promising drug delivery vehicle for transdermal delivery of CA.
Keywords: Caffeic Acid; Hydroxypropyl-β-cyclodextrin; Elastic Liposome; Drug-in-cyclodextrin-in-elastic Liposome; Skin Permeation
[References]
  1. Honeywell-Nguyen PL, Bouwstra JA, Drug Discovery Today Technol., 2, 67, 2005
  2. Otto DP, Villiers MM, Ther. Deliv., 5, 961, 2014
  3. Park SN, Lee MH, Kim SJ, Yu ER, Biochem. Biophys. Res. Commun., 435(3), 361, 2013
  4. Choi MJ, Maibach HI, Int. J. Cosmet. Sci., 27, 211, 2005
  5. Cevc G, Blume G, BBA-Biomembranes, 1104, 226, 1992
  6. Elsayed MA, Abdallah Y, Naggar F, Khalafallah M, Int. J. Pharm., 332, 1, 2007
  7. Johnson W, Int. J. Toxicol., 20, 13, 2001
  8. Han SB, Kwon SS, Jeong YM, Kong BJ, Yu ER, Park SN, Polym. Korea, 38(6), 694, 2014
  9. Park SN, Lim MS, Park MA, Kwon SS, Han SB, Polym. Korea, 36(6), 705, 2012
  10. Maestrlli F, Gonzalez-Rodriguez ML, Rabasco AM, Ghelardini C, Mura P, Int. J. Pharm., 395, 222, 2010
  11. Im NR, Kim HS, Lim JW, Kim KJ, Noh GY, Park SN, Appl. Chem. Eng., 26(5), 563, 2015
  12. Zhang W, Wang G, Falconer JR, Baguley BC, Shaw JP, Liu J, Xu H, See E, Sun J, Aa J, Wu Z, Pharm. Res., 32, 1451, 2015
  13. McCormack B, Gregoriadis G, Int. J. Pharm., 112, 249, 1994
  14. Chen J, Lu WL, Gu W, Lu SS, Chen ZP, Cai BC, Yang XX, Expert. Opin Drug. Deliv., 11, 565, 2014
  15. Chen J, Lu WL, Gu W, Lu SS, Chen ZP, Cai BC, Expert. Opin Drug. Deliv., 10, 845, 2013
  16. Cal K, Centkowska K, Eur. J. Pharm. Biopharm., 68, 467, 2008
  17. Kaur N, Puri R, Jain SK, Aaps PharmSciTech, 11, 528, 2010
  18. Loftsson T, Brewster ME, J. Pharm. Pharmacol., 63, 1119, 2011
  19. Kang NJ, Lee KW, Shin BJ, Jung SK, Hwang MK, Bode AM, Heo YS, Lee HJ, Dong Z, Carcinogenesis, 30, 321, 2009
  20. Gupta A, Maheshwari DK, Khandelwal G, J. Appl. Nat. Sci., 5, 459, 2013
  21. Astorino TA, Alkadhi KA, in Caffeine: chemistry, analysis, function and effects, Preedy VR, Eds., Royal Society of Chemistry (2012).
  22. Kim BY, Jeong JS, Kwon HJ, Lee JH, Hong SP, Kor. J. Herbol., 23, 67, 2008
  23. Fathi M, Mirlohi M, Varshosaz J, Madani G, J. Nanomater., 2013, 9, 2013
  24. Zhang M, Li J, Zhang L, Chao J, Spectroc. Acta Pt. A-Molec. Biomolec. Spectr., 71, 1891, 2009
  25. Mohan PRK, Sreelakshmi G, Muraleedharan CV, Joseph R, Vib. Spectrosc., 62, 77, 2012
  26. van den Bergh BAI, Wertz PW, Junginger HE, Bouwstra JA, Int. J. Pharm., 217, 13, 2001
  27. Shaji J, Iyer S, Asian J. Pharm., 6, 218, 2012
  28. Delrivo A, Zoppi A, Longhi MR, Carbohydr. Polym., 87, 1980, 2012
  29. Liu B, Zhao J, Liu Y, Zhu X, Zeng J, J. Agric. Food Chem., 60, 12501, 2012
  30. Gillet A, Lecomte F, Hubert P, Ducat E, Evrard B, Piel G, Eur. J. Pharm. Biopharm., 79, 43, 2011
  31. Alomrani AH, Shazly GA, Amara AA, Badran MM, Colloids Surf. B: Biointerfaces, 121, 74, 2014
  32. Guo F, Wang J, Ma M, Tan F, Li N, J. Mater. Sci. -Mater. Med., 26, 1, 2015
  33. Hommoss A, PhD Thesis, Berlin, Free University of Berlin (2009).
  34. Aggarwal N, Goindi S, Int. J. Pharm., 437, 277, 2012
  35. El Maghraby GMM, Williams AC, Barry BW, Int. J. Pharm., 276, 143, 2004
  36. Dhule SS, Penfornis P, Frazier T, Walker R, Feldman J, Tan G, He J, Alb A, John V, Pochampally R, Nanomedicine, 8, 440, 2012
  37. Agashe H, Lagisetty P, Sahoo K, Bourne D, Grady B, Awasthi V, J. Nanopart. Res., 13, 2609, 2011
  38. Shaji J, Lal M, Int. J. Curr. Pharm. Res., 6, 16, 2014
  39. Nava G, Pinon E, Mendoza L, Mendoza N, Quintanar D, Ganem A, Pharmaceutics, 3, 954, 2011
  40. Hussain A, Samad A, Ramzan M, Ahsan MN, Rehman ZU, Ahmad FJ, Drug. Deliv., 14, 1, 2014
  41. Singh HP, Tiwary AK, Jain S, Yakugaku Zasshi, 130, 397, 2010
  42. Lira MC, Ferraz MS, da Silva DG, Cortes ME, Teixeira KI, Caetano NP, Santos-Magalhaes NS, J. Incl. Phenom. Macrocycl. Chem., 64, 215, 2009
  43. Masson M, Loftsson T, Masson G, Stefansson E, J. Control. Release, 59, 107, 1999
  44. Nagarsenker MS, Amin L, Date AA, AAPS PharmSciTech, 9, 1165, 2008
  45. Chirio D, Cavalli R, Trotta F, Carlotti ME, Trotta M, J. Incl. Phenom. Macrocycl. Chem., 57, 645, 2007
[Cited By]
  1. Yang JH, Kim BS, Korean Journal of Chemical Engineering, 35(3), 792, 2018
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