This study was conducted to evaluate the mineralization of activated sludge (MAS) by a facile and environmentally friendly electro-Fenton process (EFP). The effects of initial H2O2 concentration, pH value, applied current density and operating time on MAS through determining the removal rate of chemical oxygen demand (COD) and total coliform (TC) were studied. 72% of COD was removed by indirect oxidation double-mediated based on the electro-generation of hydroxyl radical and active chlorine, under the following optimum conditions: 127mmol L.1 of hydrogen peroxide, pH=3.0, 10 mA cm.2 of DC current, 120min of operating time, and 0.22mol L.1 of NaCl as the supporting electrolyte. Only in 10 min and pH 3.0 approximately 100% of TC was removed. The findings indicated that EFP can be applied efficiently for MAS by selecting appropriate operating conditions. The bottom line is that the process is entirely effective owing to the application of green oxidants (hydroxyl radical and active chlorine) and lack of being influenced by environmental situations, which can be introduced as an alternative to current conventional methods.