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Issue
Korean Journal of Chemical Engineering,
Vol.31, No.10, 1898-1902, 2014
Removal of potentioally genotoxic impurity from fluroxamine maleate crude drug by molecularly imprinted polymer
Hashemi-Moghaddam H, Shakeri M
The present study describes the synthesis and preliminary testing of molecularly imprinted polymers (MIPs) as scavenger resins for removal of the genotoxic impurity (GTI) (2RS)-2-[[2-[[[(1E)-5-methoxy-1-[4(trifluoromethyl) phenyl] pentylidene] amino] oxy] ethyl] amino] butanedioic acid from active pharmaceutical ingredients (API). To compare the performance of this polymer, a control polymer or non-imprinted polymer (NIP) was prepared under the same conditions without the use of template molecule. The synthesized polymers were characterized by FT-IR spectroscopy. The results of the selectivity of the molecularly imprinted polymer for absorption GTI impurity through adsorption experiments reviews were compared with the adsorption of impurity by NIP. Various parameters were optimized, such as time, pH, type of eluent for elution of impurity from polymer, concentration of sample and saturation of polymer. The proposed method was applied for removal of this genotoxic impurity from Fluvoxamine maleate tablet.
Keywords: Molecularly Imprinted Polymer; Genotoxic Impurities; Fluvoxamine Maleate; Solid Phase Extraction
[References]
  1. FDA advisory committee recommends luvox (fluvoxamine) tablets for obsessive compulsive disorder, The Free Library, 1993 PR Newswire Association LLC 12 June, 2014
  2. Figgitt DP, McClellan KJ, Drugs, 60, 4, 2000
  3. Stahl SM, Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications, Cambridge University Press, 2013
  4. Wilkinson A, Courtney M, Westlind-Danielsson A, Hallnemo G, Akerman KE, J. Pharmacol. Exp. Ther., 271, 3, 1994
  5. Nicholson KL, Balster RL, Psychopharmacology, 170, 2, 2003
  6. Pharmacopoeia B A-290 4, 2007
  7. Fritz JS, Analytical solid-phase extraction, Wiley-Vch New York, 1999
  8. Hennion MC, J. Chromatogr. A, 856, 1, 1999
  9. Pichon V, Chapuis-Hugon F, Anal. Chim. Acta, 622, 1, 2008
  10. Pichon V, J. Chromatogr. A, 1152, 1, 2007
  11. Mayes A, Whitcombe M, Adv. Drug Deliv. Rev., 57, 12, 2005
  12. Spivak DA, Adv. Drug Deliv. Rev., 57, 12, 2005
  13. Mei S, Wu D, Jiang M, Lu B, Lim JM, Zhou YK, Lee YI, Microchem. J., 98, 1, 2011
  14. Blomgren A, Berggren C, Holmberg A, Larsson F, Sellergren B, Ensing K, J. Chromatogr. A, 975, 1, 2002
  15. Song S, Shi X, Li R, Lin Z, Wu A, Zhang D, Process Biochem., 43, 11, 2008
  16. Okutucu B, Onal S, Talanta, 87, 2011
  17. Caro E, Marce RM, Cormack PA, Sherrington DC, Borrull F, J. Chromatogr. B, 813, 1, 2004
  18. Muldoon MT, Stanker LH, Anal. Chem., 69, 5, 1997
  19. Baggiani C, Giovannoli C, Anfossi L, Tozzi C, J. Chromatogr. A, 938, 1, 2001
  20. Song X, Li J, Xu S, Ying R, Ma J, Liao C, Liu D, Yu J, Chen L, Talanta, 99, 2012
  21. Chapuis F, Pichon V, Lanza F, Sellergren S, Hennion MC, J. Chromatogr. A, 999, 1, 2003
  22. Claude B, Morin P, Lafosse M, Belmont AS, Haupt K, Talanta, 75, 2, 2008
  23. Hu SG, Li L, He XW, J. Chromatogr. A, 1062, 1, 2005
  24. Baggiani C, Anfossi L, Giovannoli C, Anal. Chim. Acta, 591, 1, 2007
  25. Mahony J, Nolan K, Smyth M, Mizaikoff B, Anal. Chim. Acta, 534, 1, 2005
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