The water-gas shift (WGS) reaction in the temperature range of 100-350 ℃ for various feed compositions simulating forward, reverse and real WGS conditions was studied for a series of coprecipitated mixed metal oxide catalysts of 30 wt% of CuO and 70 wt% of metal oxide (CeO2, ZnO, Cr2O3, and ZrO2) as well as for a commercial WGS catalyst (ICI 83-3). The catalysts were characterized using BET, XRD, H2-TPR and N2O dissociation studies. Among the tested catalysts, CuO-Cr2O3 showed the best activity in the forward WGS, while the commercial catalyst was the best catalyst in the real and reverse WGS reactions. The effect of Cu content in the catalyst was also studied and, in the case of the real WGS, 50 wt% CuO-Cr2O3 was more active than 30 wt% CuO-Cr2O3. H2 and CO2 were found to inhibit the forward WGS, decreasing the reaction rate substantially, particularly at temperatures below 200 oC. The inhibition effect varied depending on the tested catalyst and increased with increasing H2 or CO2 concentration. As the inhibition effect was reversible, the competitive adsorption of H2 or CO2 on the active sites has been suggested to be responsible for the effect. The high activity of the commercial catalyst in the H2 rich real WGS could be described by the difference in the H2 inhibition between the catalysts. An easily reducible copper species was found in CuO-Cr2O3 and could be attributed to the high activity in the forward WGS.