The intention of this review article is to review the knowledge about interactions in organic binary liquid mixtures. Molecular interactions in organic binary liquid mixtures are interesting due to their extensive use in many fields of solution chemistry. The thermodynamics of component molecules present in various systems interacting are particularly interesting because they display fantastic results. Studies of different organic liquid mixtures represent the different modes of interactions prevailing in the component molecules. The number of parameters required describing the properties of a given class of mixtures increases sharply with the number of segment types involved. In recent years, the theoretical and experimental investigations of interactions between unlike molecules have been conveniently carried out using excess thermodynamic functions. The properties of liquid mixtures depend on the forces between molecules and on the nature and volume of these molecules, and change with the composition of the mixtures. This change, in turn, is reflected in the thermodynamic properties of the mixtures. The influence of significant contributions of a chemical, physical and geometrical nature that change excess thermodynamic properties is considered and explained in detail.