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Issue
Korean Journal of Chemical Engineering,
Vol.31, No.1, 104-108, 2014
Effect of Scutellaria baicalensis extract on skin barrier function via peroxisome proliferator-activated receptor-α
Kim B, Kim JE, Lee SM, Kim HS
Scutellaria baicalensis extract (SBE) was investigated to determine its effects on the transactivation activity of peroxisome proliferator-activated receptors (PPAR)-responsive element (PPRE) and anti-oxidant activity for improvement of skin barrier function. The treatment with SBE resulted in a significant increase in the transactivation activity of PPRE such as PPAR-α and effect in anti-oxidant and anti-microbial activity. In addition, SBE promotes the expression of protein related to cornified envelope (CE) formation such as involucrin. Therefore, these results indicate that SBE can promote keratinocyte differentiation and restore skin barrier homeostasis, and is suggested to be an appropriate skin therapeutic agent for improving epidermal permeability barrier function.
Keywords: Peroxisome Proliferators Activated Receptors; Anti-oxidative Activity; Scutellaria baicalensis Extract
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