α-MnO2 nanowires were synthesized through a simple hydrothermal route and employed as support to obtain CuO/α-MnO2 catalysts in low temperature CO oxidation. The prepared samples were characterized by X-ray diffraction (XRD), N2 adsorption (BET), temperature programmed reduction (TPR), thermal gravimetric/differential thermal analysis (TGA/DTA), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) techniques. The results showed that the prepared samples have nanowire morphology with a size about 30-40 nm in diameter. The obtained results revealed a remarkably high activity for the prepared catalysts in low temperature CO oxidation.