Owing to the fast growth of the agricultural bioproducts industry, which requires its products to be fresh and visibly appealing, the increased use of imidacloprid pesticides has raised deep concerns about environmental effects, food quality, and the toxicity of residues. This has led to the development of various extraction methods of biochemicals and chemicals and their effective sensors for monitoring pesticide residues. We review the current commercial and nanotechnology-adopted techniques available in order to draw attention to the primary issues in the development of novel extraction and sensing systems using nanotechnology.