Korean Journal of Chemical Engineering, Vol.30, No.9, 1784-1789, 2013
Anti-inflammatory effects of silkworm hemolymph on lipopolysaccharide-stimulated macrophages
Macrophages participate in several inflammatory pathologies such as sepsis and arthritis. We investigated the effect of silkworm hemolymph (SH) on the LPS-induced pro-inflammatory macrophages. SH inhibits LPSinduced nitric oxide (NO) production in RAW 264.7 cells and murine peritoneal macrophages. The decreased NO was reflected as a decreased amount of inducible nitric oxide synthase (iNOS) mRNA and protein. It was also found that SH inhibited pro-inflammatory cytokines, IL-1β, IL-6, and TNF-α production. To elucidate the mechanism by which SH inhibits NO production and iNOS expression, we investigated that SH suppressed IκB phosphorylation, which leads to the activation of NF-κB followed by degradation of IκB. This observation suggests that SH is a potential therapeutic modulator for inflammation-associated disorders.
[References]
Janeway CA, Medzhitov R, Annu. Rev. Immunol. , 20 , 197, 2002
Raetz CR, Whitfield C, Annu. Rev. Biochem. , 71 , 635, 2002
Petros A, Bennett D, Vallance P, Lancet. , 338 , 1557, 1991
Cohen J, Nature. , 420 , 885, 2002
ter Steege JC, van de Ven MW, Forget PP, Brouckaert P, Buurman WA, Cytokine. , 10 , 115, 1998
Cheon H, Yu SJ, Yoo DH, Chae IJ, Song GG, Sohn J, Clin. Exp. Immunol. , 127 , 547, 2002
Xie QW, Kashiwabara Y, Nathan C, J. Biol. Chem. , 269 , 4705, 1994
Sha WC, Liou HC, Tuomanen EI, Baltimore D, Cell. , 80 , 321, 1995
Ha SH, Park TH, Kim SE, Biotechnol. Technol. , 10 , 401, 1996
Rhee WJ, Kim EJ, Park TH, Biotechnol. Prog. , 15 (6), 1028, 1999
Ha SH, Park TH, Biotechnol. Lett. , 19 (11), 1087, 1997
Rhee WJ, Park TH, Biochem. Biophys. Res. Commun. , 271 , 186, 2002
Choi SS, Rhee WJ, Park TH, Biotechnol. Prog. , 18 (4), 874, 2002
Rhee WJ, Kim EJ, Park TH, Biophys. Res. Commun. , 295 , 779, 2002
Kim EJ, Rhee WJ, Park TH, Biochem. Biophys. Res. Commun. , 285 (2), 224, 2001
Kim EJ, Rhee WJ, Park TH, Biotechnol. Prog. , 20 (1), 324, 2004
Kim EJ, Park HJ, Park TH, Biochem. Biophys. Res. Commun. , 308 (3), 523, 2003
Kim EJ, Park TH, Biotechnol. Bioprocess Eng. , 8 , 76, 2003
Choi SS, Rhee WJ, Kim EJ, Park TH, Biotechnol. Bioeng. , 95 (3), 459, 2006
Wang Z, Park JH, Park HH, Tan WS, Park TH, Biotechnol. Bioeng. , 108 (7), 1634, 2011
Park JH, Wang Z, Jeong HJ, Park HH, Kim BG, Tan WS, Choi SS, Park TH, Appl. Microbiol. Biotechnol. , 96 (3), 671, 2012
Joosten CE, Park TH, Shuler ML, Biotechnol. Bioeng. , 83 (6), 695, 2003
Choi SS, Rhee WJ, Park TH, Biotechnol. Bioeng. , 91 (7), 793, 2005
Rhee WJ, Lee EH, Park TH, Biotechnol. Bioprocess Eng. , 14 , 645, 2009
Rhee WJ, Lee EH, Park JH, Lee JE, Park TH, Biotechnol. Prog. , 23 (6), 1441, 2007
D’Acquisto F, May MJ, Ghosh S, Mol. Interv. , 2 , 22, 2002
Starnes HF, Pearce MK, Tewari A, Yim JH, Zou JC, Abrams JS, J. Immunol. , 145 , 4185, 1990
Rollins BJ, Mol. Med. Today. , 2 , 198, 1996
Van Kaer L, Immunol. Cell Biol. , 82 , 315, 2004
Ghosh S, May MJ, Kopp EB, Annu. Rev. Immunol. , 16 , 225, 1998
Xaus J, Comalada M, Valledor AF, Lioberas J, Lopez-Soriano F, Argiles JM, Bogdan C, Celada A, Blood. , 15 , 3823, 2000
Koizumi N, Morozumi A, Imamura M, Tanaka E, Iwahana H, Sato R, Eur. J. Biochem. , 248 , 217, 1997
Koizumi N, Imamura M, Kadotani T, Yaoi K, Iwahana H, Sato R, Febs Lett. , 443 , 139, 1999
Kamimura M, Nakahara Y, Kanamori Y, Tsuzuki S, Hayakawa Y, Kiuchi M, Biochem. Biophys. Res. Commun. , 286 (1), 67, 2001
Ishii K, Hamamoto H, Kamimura M, Nakamura Y, Noda H, Imamura K, Mita K, Sekimizu K, J. Biol. Chem. , 285 , 28635, 2010
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