The vast growth of the manufacturing world is producing a massive amount of wastewater from a wide range of industrial applications disposed into surface water. Undoubtedly, these effluents contain a variety of high-toxic compounds that pose a real challenge and dislocate the environment. The reverse osmosis (RO) process is recognized as a superior method due to its reliability in generating a roughly pure reuse water at a plausible cost. However, the literature has a shortage of comprehensive studies to simultaneously eliminate organic and non-organic compounds from wastewater using a predefined multi stage direct pass operation of a spiral wound module of RO process. To systematically carry out this, a mathematical model developed by the same author has been modified to critically predict the efficiency of RO process towards the simultaneous removal of multi-component from wastewater. For this system, the simulation introduces realistic operating circumstances that correspond to a high rejection of the targeted chemicals. By optimizing the design operating conditions, the accompanying treatment process' consistency and effectiveness are also increased. As a result, there was a noticeable decline in the unintended release of the harmful substances into the recycled water within a fixed specific energy consumption.