Designing the process layout in a chemical plant is a complex and multidisciplinary task requiring input from experts in fields such as chemical, civil, mechanical, and instrument engineering. Plant layout entails the allocation of a given number of facilities on a given piece of land. Determining the optimal distribution of facilities in a plant requires an optimization calculation, including a variety of distance constraints, one of which is related to process safety. A few approaches have been taken to transform consequence analysis, such as toxic gas dispersion and its mitigation as well as the risks of fire and explosions, into mathematical equations as constraints of an optimization problem. An optimization problem with constraints related to safety is not easy to solve given limitations such as nonlinearity, uncertainty, and ethical difficulties in converting human life to costs for calculation purposes. However, safety concerns have increased to the point that developing this type of approach is necessary. The objective of this study was to review the current methodologies for plant layout optimization and to resolve facility siting issues. Process safety concepts are considered with a view to identifying gaps and issues with current methods in order to develop better methodologies for designing safer layouts.
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