Overall
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received April 6, 2026
Accepted June 5, 2026
Available online October 26, 2026
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Most Cited
Development of an Efficient Method for Removing Residual Solvents from Purified Paclitaxel by Ultrasound-Assisted Fractional Precipitation
https://doi.org/10.1007/s11814-026-00768-2
Abstract
While prior research has predominantly focused on utilizing ultrasound to accelerate the precipitation of paclitaxel, this
study uniquely investigates the integration of ultrasonic cavitation into fractional precipitation to optimize the efficiency
of residual solvent removal from purified paclitaxel. The underlying mechanism reveals that increasing ultrasonic power
(0–480 W) induces significant particle size reduction, thereby enlarging the specific surface area and accelerating solvent
elution during the subsequent drying stage. Drying kinetics followed the Page model, with the methanol/water system
demonstrating a higher drying rate constant than the acetone/water system. While 10 min of ultrasonic irradiation was
insufficient to meet regulatory standards, a 20-min treatment successfully reduced residual solvents to within ICH Q3C
guidelines (acetone<5,000 ppm; methanol<3,000 ppm) under optimized conditions (480 W for methanol; 380–480 W
for acetone). These results validate ultrasonic cavitation as a high-efficiency auxiliary process specifically for rigorous
solvent elimination, offering a quantitative basis for enhancing energy efficiency and reducing costs in large-scale paclitaxel
production.
