Transistor-based platforms off er several advantages for chemical and biological sensing application over conventional electrochemical

systems, including enhanced sensitivity, portability, cost-eff ectiveness, and biocompatibility. However, these

devices often require functionalization with specifi c recognition units, introducing challenges related to the chemical stability

of conjugated units, their conformation, and Debye length eff ects. Lipid-based biomembranes, particularly supported lipid

bilayers (SLBs), can mimic the native architecture of cell membranes, acting as biointerfaces that facilitate signal transduction

between extra- and intracellular environments. They also provide selective permeability to ions, specifi city to biochemicals,

as well as ease of integration with diverse materials. Over the past two decades, researchers have focused on integrating

biomembranes with transistor platforms to advance bioelectronic sensing technologies and enhance the understanding and

monitoring of biological processes. This review explores integrating various lipid-based biomembrane types with transistorbased

devices. We review fundamental techniques for producing and characterizing biomembranes, the advantages and limitations

of diff erent transistor types, and their working principles in biomembrane-based systems. Additionally, we highlight

recent developments in biomembrane-integrated sensing platforms, including their incorporation into transistor architectures,

further functionalization with biorecognition units, and applications in detecting analytes.