Bioelectronic devices represent a transformative advancement in medical technology, redefi ning diagnosis, treatment, and

monitoring of various health conditions. These devices bridge the gap between electronic systems and human physiology

by leveraging the electrical dynamics of biological systems, particularly through the control of ion dynamics. Ion dynamics

are essential, as they drive the activation and deactivation of ion channels during neuronal communication and therapeutic

treatments, thus enhancing device effi cacy in clinical settings. However, traditional bioelectronic approaches face challenges

such as sensitivity, specifi city, and potential tissue damage from continuous voltage application. Iontronics, which integrates

ionic and electronic functionalities, emerges as a promising solution to address these issues, employing non-Faradaic processes

to prevent charge transfer across interfaces, thereby enhancing safety and performance in bioelectronic applications.

This review examines the fi eld of iontronics within bioelectronics, highlighting its crucial role in advancing bioelectronic

medicine towards more eff ective and personalized health monitoring. We explore the latest advancements in iontronics for

tactile perception, biochemical and electrophysiological sensing, neural interfaces, and therapeutic treatments. The discussion

concludes with future perspectives and challenges in iontronic-based bioelectronic devices, emphasizing the need for

continued innovation in iontronic materials to further refi ne the integration of these technologies within the medical fi eld.