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- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received August 5, 2024
Accepted February 2, 2025
Available online April 25, 2025
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Most Cited
Isotherm, Kinetic, and Thermodynamic Studies for Negative Pressure Cavitation Adsorption of Paclitaxel from Culture Supernatants of Taxus chinensis onto Diaion HP-20
https://doi.org/10.1007/s11814-025-00414-3
Abstract
In this study, a negative pressure cavitation adsorption method was developed to effi ciently recover paclitaxel from Taxus
chinensis culture supernatants using Diaion HP-20 as an adsorbent. The equilibrium adsorption data were applied to Langmuir,
Freundlich, Dubinin–Radushkevich, and Elovich isotherms, and the Langmuir isotherm was found to be the most
feasible. The kinetic data were in good agreement with the pseudo-second-order model, and intraparticle diff usion played a
dominant role in the adsorption rate of paclitaxel according to the intraparticle diff usion model. The time for the adsorption
to reach equilibrium was shortened by more than eight times at all negative pressures (− 50 to − 200 mmHg) compared to
the conventional adsorption. In addition, as the negative pressure increased, the maximum adsorption capacity, adsorption
rate constant, intraparticle diff usion rate constant, and intraparticle diff usion coeffi cient increased. The values of the thermodynamic
parameters indicated that the adsorption was endothermic and spontaneous. As the negative pressure intensity
increased at a given adsorption capacity (q e = 60–100 mg/g), the isosteric heat of adsorption decreased and the adsorbent
surface became more energetically homogeneous.
