Recently, ozone catalytic oxidation technology has been widely concerned because it can effi ciently remove VOCs at low

temperatures. However, the infl uence of diff erent factors on the catalytic ozonation of VOCs, especially of multi-component

VOCs, is still indeterminate. Herein, the eff ect of each reaction parameter on catalytic ozonation of single- and multi-component

of toluene and dimethyl carbonate was systematically evaluated using a highly effi cient catalyst (Mn/Y). Simultaneously,

a multiple quadratic regression model was established by response surface methodology to compare the diff erence of

the contribution of diff erent reaction conditions to single- and multi-component VOCs reaction systems. It was found that

the eff ect of diff erent factors on VOCs conversion followed reaction temperature > space velocity > input concentration of

ozone. In addition, the eff ect of the reaction conditions on ozone conversion in DMC reaction system and CO x selectivity

in toluene reaction system (reaction temperature > input concentration of ozone > space velocity) is diff erent from the other

reaction systems (reaction temperature > space velocity > input concentration of ozone). Satisfactorily, the results of the catalytic

reaction experiment are highly consistent with the data fi tted by the multiple quadratic regression model. It can provide

theoretical guidance for optimizing the reaction parameters of catalytic ozonation of VOCs in diff erent reaction systems.