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- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received November 18, 2024
Revised February 9, 2025
Accepted April 18, 2025
Available online July 25, 2025
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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A Prospective Technology: Hemostasis with α-Cyanoacrylate Medical Adhesive via Electrostatic Spray Deposition Mode
https://doi.org/10.1007/s11814-025-00448-7
Abstract
α-Cyanoacrylate medical adhesive is one of the materials that can achieve rapid hemostasis. However, its traditional delivery
methods have many problems in practical operation. In this study, the α-ethyl cyanoacrylate (ECA) plasticized by biodegradable
material polycaprolactone was used as precursor, and a comparative study was conducted on the delivery of ECA using
two promising methods of electrostatic spinning technology (EST) and electrostatic spray deposition (ESD). Micromorphology
analyses showed that the surface of the fi lm obtained by ESD on aluminum foil exhibited relatively uniform characteristics
compared with EST. The particle size distribution by ESD was more uniform than that of EST under the same working
parameters. The peel strength and tensile strength of ESD fi lm were 39.2% and 13.6%, respectively, higher than those of EST
fi lm, and ESD fi lm folded 90° repeatedly up to 600 times without breaking. What’s more, the use of ESD could improve the
wettability of ECA fi lm, which would be conducive to fi lm biodegradation. Biological surface coating experiment exhibited
that ESD fi lm could complete and continuous attachment to the surface of fresh pig liver with a good sealing eff ect. The
results indicated that ESD had more prominent effi ciency and adaptability for CA medical hemostasis in the medical fi eld.
