The importance of tryptophan in both human and animal nutrition continues to drive its demand and market growth. To

enhance the usability of tryptophan products, such as fl owability, bulk density, and mixing effi ciency, the fl uidized bed

granulation process plays a critical role in the industrial production of tryptophan from microbial fermentation. This process

involves a simplifi ed method of evaporation and granulation to effi ciently produce commercial granular products. This study

conducted a solid fl ow analysis for scaling up fl uidized bed granulators in the manufacturing of calcium–tryptophan granules,

focusing on the solid fl ow characteristics, the fl ow regime within the granulator, and the granulator's design considerations.

The scale-up case for calcium–tryptophan granules revealed that the bubbling fl uidization fl ow regime occurred similarly

at both pilot and plant scales. Then, the transport disengaging height to minimize fi ne particle loss inside the fl uidized bed

granulator and the entrainment rate to secure the capacity of entrained particle recovery equipment such as cyclones or bag

fi lters were determined to obtain basic design data for scale-up of the fl uidized bed granulation process.