Articles & Issues
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received April 11, 2025
Revised July 1, 2025
Accepted July 7, 2025
Available online January 1, 1970
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
All issues
Lauroyl Lysine Continuous Injection Synthesis via Schotten–Baumann Reaction pH Optimization as Synthetic Amino Acid Derivative
https://doi.org/10.1007/s11814-025-00517-x
Abstract
This research focuses on identifying optimal synthesis conditions for lauroyl lysine, an amino acid derivative widely used
in the cosmetics industry. The eff ect of pH on reaction rate and selectivity was quantitatively assessed through systematic
variations within the range between pH 10 and pH 13, and the reaction conditions were subject to a continuous slow precursor
injection technique as alternative to batch-type reaction. This results in optimal pH conditions and the establishment of
a synthesis via Schotten–Baumann reaction process on a laboratory scale, yielding from 97.77 to 55.20% range. This study
will contribute to maximizing the industrial scale-up synthesis effi ciency of lauroyl lysine and expanding its application
potential in the cosmetics industry, reducing manufacturing costs and expect the possibility of commercial production.
