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- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
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Received October 28, 2022
Revised December 12, 2022
Accepted December 26, 2022
- Acknowledgements
- This research was supported by the Chung-Ang University Graduate Research Scholarship in 2021 (Jayoung Chae) and by the Research Program funded by the Korea Centers for Disease Control and Prevention (2021-ER180200). This study was also supported by a grant from the National Research Foundation of Korea (NRF), funded by the Korean Government (MSIT) (No. 2020R1 A5A1018052).
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Trends in nano-platforms for the treatment of viral infectious diseases
Kevin Kent Vincent Canlas1
Joohye Hong1
Jayoung Chae1
Hyun Wook Seo2
Shin Hyuk Kang3†
Jonghoon Choi1†
Hansoo Park1†
1School of Integrative Engineering, Chung-Ang University, Seoul 06974, Korea 2Division of Chronic Viral Disease, Center for Emerging Virus Research, National Institute of Health, Cheongju 28159, Korea 3Departments of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul 06973, Korea
kangshinhyeok@cau.ac.kr, nanomed@cau.ac.kr, heyshoo@cau.ac.kr
Korean Journal of Chemical Engineering, April 2023, 40(4), 706-713(8), 10.1007/s11814-023-1388-0
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Abstract
Viral diseases have always been a major health issue, from the currently eradicated poliovirus to the still
unresolved human immunodeficiency virus, and have since become a recent global threat brought about by the
COVID-19 pandemic. Pathogenic viruses easily spread through various means such as contaminated food and water
intake, exchange of bodily fluids, or even inhalation of airborne particles mainly due to their miniscule size. Furthermore, viral coats contain virulent proteins which trigger assimilation into target cells on contact through either direct
penetration or induction of endocytosis. In some viruses their outer envelope contains masking ligands that create a
means of escape from detection of immune cells. To deal with the nanometer size range and biomolecular-based invasion mechanism, nanoparticles are highly suitable for the treatment. The review highlights the progress in nanoparticle
technology, particularly viral therapeutics, including therapeutic strategies and existing clinical applications
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