Articles & Issues
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
- Publication history
-
Received September 24, 2020
Accepted December 19, 2020
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
Ultrasound-based fractional precipitation for the purification of (+)-dihydromyricetin
Department of Chemical Engineering, Kongju National University, Cheonan 31080, Korea
Korean Journal of Chemical Engineering, March 2021, 38(3), 480-484(5), 10.1007/s11814-020-0734-8
Download PDF
Abstract
The purification efficiency of (+)-dihydromyricetin, a bioactive plant flavonoid, was remarkably improved through ultrasound-based fractional precipitation. The precipitation time (up to 30 min) taken to obtain (+)-dihydromyricetin with high purity (87.01-91.66%) and yield (90.63-92.00%) through the ultrasonic fractional precipitation (ultrasonic power: 80-250W) was shortened by 40-fold as compared to the conventional method (up to 1200 min). In addition, the precipitation rate constant was increased by 12- to 18-fold, but the activation energy was decreased to between -5,787 J/mol and -6,526 J/mol, and thereby the precipitation rate was improved. Furthermore, the size of the precipitate was reduced by 5.1- to 5.5-fold, while the diffusion coefficient was increased by 6.4- to 6.9-fold.
References
Zheng XJ, Xiao H, Zeng Z, Sun ZW, Lei C, Dong JZ, Wang Y, J. Funct. Foods, 9, 290 (2014)
Li F, Raza A, Wang YW, Xu XQ, Chen GH, Phcog. Mag., 13, 446 (2017)
Ji SB, Kim JH, Korean Chem. Eng. Res., 56(3), 370 (2018)
Du Q, Cai W, Xia M, Ito Y, J. Chromatogr. A, 973, 217 (2002)
Ye L, Wang H, Duncan SE, Eigel WN, O’Keefe SF, Food Chem., 172, 416 (2015)
Song X, Ren Q, CN Patent, 1,288,892 (2001).
Zhang Y, CN Patent, 1,393,443 (2003).
Lee KH, Kim JH, Biotechnol. Bioprocess Eng., 13, 274 (2008)
Kim MK, Kim JH, Korean J. Microbiol. Biotechnol., 42, 25 (2014)
Seo HW, Kim JH, Process Biochem., 87, 238 (2019)
Davies LA, Dargue A, Dean JR, Deary ME, Ultrason. Sonochem., 23, 424 (2015)
Kang HJ, Kim JH, Process Biochem., 99, 316 (2020)
Jordens J, Coker ND, Gielen B, Gerven TV, Braeken L, Ultrason. Sonochem., 26, 64 (2015)
Ha GS, Kim JH, Korean J. Chem. Eng., 34(9), 2451 (2017)
Park JN, Kim JH, Process Biochem., 53, 224 (2017)
Wohgemuth K, Kordylla A, Ruether F, Schembecker G, Chem. Eng. Sci., 64(19), 4155 (2009)
Guo Z, Zhang M, Li H, Wang J, Kougoulos E, J. Cryst. Growth, 273(3-4), 555 (2005)
Khadka P, Ro J, Kim H, Kim I, Kim JT, Kim H, Cho JM, Yun G, Lee J, Asian J. Pharm. Sci., 9, 304 (2014)
Kim MJ, Kim JH, Korean Chem. Eng. Res., 54(2), 278 (2016)
Ma D, Marshall JS, Wu J, J. Acoust. Soc. Am., 144, 3496 (2018)
Guo Z, Jones AG, Li N, Chem. Eng. Sci., 61, 1617 (2008)
Wolloch L, Kost J, J. Control. Release, 148, 204 (2010)
Li F, Raza A, Wang YW, Xu XQ, Chen GH, Phcog. Mag., 13, 446 (2017)
Ji SB, Kim JH, Korean Chem. Eng. Res., 56(3), 370 (2018)
Du Q, Cai W, Xia M, Ito Y, J. Chromatogr. A, 973, 217 (2002)
Ye L, Wang H, Duncan SE, Eigel WN, O’Keefe SF, Food Chem., 172, 416 (2015)
Song X, Ren Q, CN Patent, 1,288,892 (2001).
Zhang Y, CN Patent, 1,393,443 (2003).
Lee KH, Kim JH, Biotechnol. Bioprocess Eng., 13, 274 (2008)
Kim MK, Kim JH, Korean J. Microbiol. Biotechnol., 42, 25 (2014)
Seo HW, Kim JH, Process Biochem., 87, 238 (2019)
Davies LA, Dargue A, Dean JR, Deary ME, Ultrason. Sonochem., 23, 424 (2015)
Kang HJ, Kim JH, Process Biochem., 99, 316 (2020)
Jordens J, Coker ND, Gielen B, Gerven TV, Braeken L, Ultrason. Sonochem., 26, 64 (2015)
Ha GS, Kim JH, Korean J. Chem. Eng., 34(9), 2451 (2017)
Park JN, Kim JH, Process Biochem., 53, 224 (2017)
Wohgemuth K, Kordylla A, Ruether F, Schembecker G, Chem. Eng. Sci., 64(19), 4155 (2009)
Guo Z, Zhang M, Li H, Wang J, Kougoulos E, J. Cryst. Growth, 273(3-4), 555 (2005)
Khadka P, Ro J, Kim H, Kim I, Kim JT, Kim H, Cho JM, Yun G, Lee J, Asian J. Pharm. Sci., 9, 304 (2014)
Kim MJ, Kim JH, Korean Chem. Eng. Res., 54(2), 278 (2016)
Ma D, Marshall JS, Wu J, J. Acoust. Soc. Am., 144, 3496 (2018)
Guo Z, Jones AG, Li N, Chem. Eng. Sci., 61, 1617 (2008)
Wolloch L, Kost J, J. Control. Release, 148, 204 (2010)
