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Received November 8, 2016
Accepted December 24, 2016
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Electrochemical sensor for selective detection of norepinephrine using graphene sheets-gold nanoparticle complex modified electrode
Department of Chemical & Biomolecular Engineering, Sogang University, Seoul 04107, Korea 1School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea
bkoh@sogang.ac.kr
Korean Journal of Chemical Engineering, April 2017, 34(4), 1129-1132(4)
https://doi.org/10.1007/s11814-016-0363-4
https://doi.org/10.1007/s11814-016-0363-4
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Abstract
Neural diseases, like Alzheimer’s (AD) and Parkinson’s (PD) are widely expanding portions of neurodegenerative diseases, are related to norepinephrine (NE) concentration with proportional correlation. However, quantification of NE is quite difficult because NE coexists with ascorbic acid (AA) and uric acid (UA), which interferes with detecting NE in biological fluid. We fabricated a multi-modified electrode with reduced graphene oxide sheets (GS) and gold nanoparticles (GNPs) for highly selective and sensitive detection of NE. Thus, GS-GNPs modified electrode could enhance the sensitivity for detection of NE, as well as highly sensitive manner with AA. Compared with recent studies, our newly developed sensor appears to have not only a wide detection range (0.2-10 μM), but also superior detection limit (200 nM) in presence of 2000 times higher concentration of AA.
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References
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Hubbard KE, Wells A, Owens TS, Tagen M, Fraga CH, Stewart CF, Biomed. Chromatogr., 24, 626 (2010)
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van Noort D, Mandenius CF, Biosens. Bioelectron., 15, 203 (2000)
Bansal C, Sarkar S, Mishra A, Abraham T, Lemier C, Hahn H, Sci. Mater., 56, 705 (2007)
Mao K, Wu D, Li Y, Ma H, Ni Z, Yu H, Luo C, Wei Q, Du B, Anal. Biochem., 422, 22 (2012)
Li XL, Zhang GY, Bai XD, Sun XM, Wang XR, Wang E, Dai HJ, Nat. Nanotechnol., 3(9), 538 (2008)
Shan C, Yang H, Han D, Zhang Q, Ivaska A, Niu L, Biosens. Bioelectron., 25, 1504 (2010)
Singh V, Joung D, Zhai L, Das S, Khondaker SI, Seal S, Prog. Mater. Sci., 56(8), 1178 (2011)
Chen L, Tang Y, Wang K, Liu C, Luo S, Electrochem. Commun., 13, 133 (2011)
Yao YI, Ding Y, Ye LS, Xia XH, Carbon, 44, 61 (2006)
Sass JO, Skladal D, Brunner-Krainz M, Metabolic Brain Disease, 14, 67 (1999)
Deletioglu D, Hasdemir E, Solak AO, Curr. Anal. Chem., 6, 203 (2010)
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Moghaddam HM, Beitollahi H, Int. J. Electrochem. Sci., 6, 6503 (2011)
Ma X, Chen M, Li X, Int. J. Electrochem. Sci., 7, 991 (2012)
