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Received July 15, 2012
Accepted December 2, 2012
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Effects of fruiting body extracts of Lentinus edodes cultivated using corn cob on biological activities
Jong-Soo Kim
Dubok Choi1
Bock-Gie Jung2
Bong-Joo Lee2
Geum-Sook Lim3
Myung Koo Lee1
Wol-Suk Cha4
Hoon Cho4†
School of Chemical Engineering, Chonbuk National University, Jeonju 561-756, Korea 1Department of Pharmacy, College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea 2College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Korea 3Interdisciplinary Program of Perfume and Cosmetics, Chonnam National University Graduate School, Gwangju 500-757, Korea 4Department of Polymer Science & Engineering, Chosun University, Gwangju 501-759, Korea
hcho@chosun.ac.kr
Korean Journal of Chemical Engineering, April 2013, 30(4), 906-912(7)
https://doi.org/10.1007/s11814-012-0209-7
https://doi.org/10.1007/s11814-012-0209-7
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Abstract
We investigated the antioxidant, nitrite scavenging, immune-enhancing and antimicrobial effects of the Lentinus edodes fruiting body extracts (LEFB extract) cultivated in the solid state using corn cob. The CAT, SOD and GSH-Px activities in the LEFB extract (400mg)-fed group were approximately 1.70, 1.64, and 2.2 times higher than those of the control group. The nitrite scavenging activity was highest (86.4%) when the LEFB extract concentration was 600 μg/mL. The immune-enhancing and antimicrobial effects of LEFB extract after an experimental Bordetella_x000D_
bronchiseptica infection were examined. White blood and neutrophil in the LEFB extract (400 mg)-fed group were approximately 2.1 and 2.2 times higher, respectively, than those of the control group. The total leukocyte was 30% higher than that of the control group. The CD4 : CD8 ratio in the LEFB extract (200 mg)-fed group was increased approximately 54.3% compared to that of the control group. The levels of TNF-α and IFN-γ mRNA expression in the LEFB extract (400 mg)-fed group were approximately 49 and 50% lower than those of the control group. The bacteria and inflammatory cell in the LEFB extract (400 mg)-fed group were approximately 48.7 and 29% lower, respectively, than that of the control group. These results suggest that the LEFB extract may be useful in immune function improvement.
Keywords
References
Chang ST, Int. J. Med. Mushr., 1, 387 (1999)
Lee H, Song M, Yu Y, Hwang S, Biochem. Eng. J., 15, 93 (2003)
Park EM, Kim SJ, Ye EJ, Bae MJ, Jo KC, J. Korean Soc. Food Sci. Nutr., 34, 323 (2005)
Lee SJ, Moon SM, Kim T, Kim JY, Seo JS, Kim DS, Kim J, Kim YJ, Park YL, Korean J. Microbiol. Biotechnol., 4, 362 (2003)
Kuforiji OO, Fasidi IO, Bioresour. Technol., 12, 4275 (2008)
Bhak G, Song MY, Lee S, Hwang S, Biotechnol. Lett., 27(20), 1537 (2005)
Cristina SR, Ana GR, Isabel P, Gemma JB, Francisco RM, Wichers H, Int. Biodeter. Biodegrad., 57, 37 (2006)
Jang KH, Shin KO, Kim SD, Korean J. Food Preserv., 12, 379 (2005)
Zdena HK, Julia E, Anna E, Ind. Crops Products., 9, 101 (1999)
Rivas B, Dominguez JM, Dominguez H, Parajo JC, Enzyme Microb. Technol., 31(4), 431 (2002)
Cao Q, Xie KC, Bao WR, Shen SG, Bioresour. Technol., 94(1), 83 (2004)
Perotti NI, Molina OE, Biological Waste., 26, 125 (1988)
Tsai WT, Chang CY, Wang SY, Chang CF, Chien SF, Sun HF, Bioresour. Technol., 78(2), 203 (2001)
Ninawe S, Kuhad RC, J. Appl. Microbiol., 99(5), 1141 (2005)
Tada K, Horiuchi JI, Kanno T, Kobayashi M, J. Biosci. Bioeng., 98(3), 228 (2004)
Ki JS, Seo GY, Kang IS, Ahn BK, Choi DB, J. Adv. Eng.Technol., 3, 115 (2010)
Cha WS, Park SS, Kim SJ, Choi D, Bioresour. Technol., 101(16), 6475 (2010)
Kim BH, Choi DB, Piao YL, Park SS, Lee MK, Cha WS, Chang YC, Cho H, Korean J. Chem. Eng., 29(10), 1393 (2012)
Yap AT, Ng ML, Inter. J. Med. Mush., 5, 339 (2003)
Lee HJ, Seo YW, Biotechnol. Bioprocess Eng., 11, 13 (2006)
Choi DB, Nam HG, Cha WS, Korean J. Chem. Eng., 23(2), 241 (2006)
Choi DB, Park SS, Ding JL, Cha WS, Biotechnol. Bioprocess Eng., 12, 516 (2007)
Cha WS, Ding JL, Choi DB, Biotechnol. Bioprocess Eng., 14, 232 (2009)
Choi DB, Kim YS, Nam HG, Shin HJ, Na MS, Choi OY, Lee HD, Cha WS, Korean J. Chem. Eng., 28(5), 1266 (2011)
Choi DB, Cho KA, Na MS, Choi HS, Kim YO, Lim DH, Cho SJ, Cho H, J. Ind. Eng. Chem., 14(6), 765 (2008)
Choi HS, Lee MJ, Na MS, Lee MY, Choi DB, J. Ind. Eng. Chem., 15(2), 275 (2009)
Lim DH, Choi DB, Choi OY, Cho KA, Kim R, Choi HS, Cho H, J. Ind. Eng. Chem., 17(3), 510 (2011)
Shahidi F, Wanasundara PKJ, Crit. Rev. Food Sci. Nutr., 32, 67 (1992)
Beckman JS, Koppenol WH, Am. J. Phys., 217, 1421 (1996)
Jung BJ, Ko JH, Choi SJ, Koh HB, Yoon SH, Han DU, Lee BJ, J. Vet. Med. Sci., 72, 1195 (2010)
MacMicking J, Xie QX, Nathan C, Annu. Rev. Immunol., 15, 323 (1997)
Moncada S, Palmer RMJ, Higgs EA, Pharmacol. Rev., 43, 109 (1991)
Ghezzi P, Cerami A, Mol. Biotechnol., 31, 239 (2005)
Branellec D, Chouaib S, Pathol. Biol., 39, 230 (1991)
Choi DB, Lee JH, Kim YS, Na MS, Choi OY, Lee HD, Lee MK, Cha WS, Korean J. Chem. Eng., 28(6), 1427 (2011)
Lee H, Song M, Yu Y, Hwang S, Biochem. Eng. J., 15, 93 (2003)
Park EM, Kim SJ, Ye EJ, Bae MJ, Jo KC, J. Korean Soc. Food Sci. Nutr., 34, 323 (2005)
Lee SJ, Moon SM, Kim T, Kim JY, Seo JS, Kim DS, Kim J, Kim YJ, Park YL, Korean J. Microbiol. Biotechnol., 4, 362 (2003)
Kuforiji OO, Fasidi IO, Bioresour. Technol., 12, 4275 (2008)
Bhak G, Song MY, Lee S, Hwang S, Biotechnol. Lett., 27(20), 1537 (2005)
Cristina SR, Ana GR, Isabel P, Gemma JB, Francisco RM, Wichers H, Int. Biodeter. Biodegrad., 57, 37 (2006)
Jang KH, Shin KO, Kim SD, Korean J. Food Preserv., 12, 379 (2005)
Zdena HK, Julia E, Anna E, Ind. Crops Products., 9, 101 (1999)
Rivas B, Dominguez JM, Dominguez H, Parajo JC, Enzyme Microb. Technol., 31(4), 431 (2002)
Cao Q, Xie KC, Bao WR, Shen SG, Bioresour. Technol., 94(1), 83 (2004)
Perotti NI, Molina OE, Biological Waste., 26, 125 (1988)
Tsai WT, Chang CY, Wang SY, Chang CF, Chien SF, Sun HF, Bioresour. Technol., 78(2), 203 (2001)
Ninawe S, Kuhad RC, J. Appl. Microbiol., 99(5), 1141 (2005)
Tada K, Horiuchi JI, Kanno T, Kobayashi M, J. Biosci. Bioeng., 98(3), 228 (2004)
Ki JS, Seo GY, Kang IS, Ahn BK, Choi DB, J. Adv. Eng.Technol., 3, 115 (2010)
Cha WS, Park SS, Kim SJ, Choi D, Bioresour. Technol., 101(16), 6475 (2010)
Kim BH, Choi DB, Piao YL, Park SS, Lee MK, Cha WS, Chang YC, Cho H, Korean J. Chem. Eng., 29(10), 1393 (2012)
Yap AT, Ng ML, Inter. J. Med. Mush., 5, 339 (2003)
Lee HJ, Seo YW, Biotechnol. Bioprocess Eng., 11, 13 (2006)
Choi DB, Nam HG, Cha WS, Korean J. Chem. Eng., 23(2), 241 (2006)
Choi DB, Park SS, Ding JL, Cha WS, Biotechnol. Bioprocess Eng., 12, 516 (2007)
Cha WS, Ding JL, Choi DB, Biotechnol. Bioprocess Eng., 14, 232 (2009)
Choi DB, Kim YS, Nam HG, Shin HJ, Na MS, Choi OY, Lee HD, Cha WS, Korean J. Chem. Eng., 28(5), 1266 (2011)
Choi DB, Cho KA, Na MS, Choi HS, Kim YO, Lim DH, Cho SJ, Cho H, J. Ind. Eng. Chem., 14(6), 765 (2008)
Choi HS, Lee MJ, Na MS, Lee MY, Choi DB, J. Ind. Eng. Chem., 15(2), 275 (2009)
Lim DH, Choi DB, Choi OY, Cho KA, Kim R, Choi HS, Cho H, J. Ind. Eng. Chem., 17(3), 510 (2011)
Shahidi F, Wanasundara PKJ, Crit. Rev. Food Sci. Nutr., 32, 67 (1992)
Beckman JS, Koppenol WH, Am. J. Phys., 217, 1421 (1996)
Jung BJ, Ko JH, Choi SJ, Koh HB, Yoon SH, Han DU, Lee BJ, J. Vet. Med. Sci., 72, 1195 (2010)
MacMicking J, Xie QX, Nathan C, Annu. Rev. Immunol., 15, 323 (1997)
Moncada S, Palmer RMJ, Higgs EA, Pharmacol. Rev., 43, 109 (1991)
Ghezzi P, Cerami A, Mol. Biotechnol., 31, 239 (2005)
Branellec D, Chouaib S, Pathol. Biol., 39, 230 (1991)
Choi DB, Lee JH, Kim YS, Na MS, Choi OY, Lee HD, Lee MK, Cha WS, Korean J. Chem. Eng., 28(6), 1427 (2011)
