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Language: English

Conflict of Interest: In relation to this article, we declare that there is no conflict of interest.

Publication history: Received April 26, 2012
Accepted August 14, 2012

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of ion exchange resin on increased surface area crystallization process for purification of vancomycin

Eun-A Kwak Sung-Jae Kim Jin-Hyun Kim^†

Department of Chemical Engineering, Kongju National University, Cheonan 330-717, Korea

Korean Journal of Chemical Engineering, November 2012, 29(11),
10.1007/s11814-012-0135-8

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Abstract

We investigated the effects of ion exchange resins on the efficiency of crystallization with an increased surface area for the purification of vancomycin. As surface area-increasing materials, diverse types of ion exchange resin were used to increase the surface area per working volume (S/V). When the S/V was increased, in cation exchange resin Amberlite 200, Amberlite IR 120 (Na), and Amberlite IRC 50 and in anion exchange resin Amberlite IRA 400 (Cl) and Amberlite IRA 910 (Cl), vancomycin crystals were successfully generated. The yield of vancomycin increased_x000D_ (>97%), and the time necessary for crystallization was reduced dramatically (reduced from 24 hr to 12 hr). On the other hand, the purity of the vancomycin was approximately 95% and was not affected by increasing S/V. Use of an ion exchange resin also resulted in the production of smaller vancomycin crystals than in the absence of ion exchange resin.

Keywords

Vancomycin Crystallization Purification Surface Area per Working Volume (S/V) Ion Exchange Resin

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