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- In relation to this article, we declare that there is no conflict of interest.
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Received March 23, 2007
Accepted April 25, 2007
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Effect of essential and nonessential amino acid compositions on the in vitro behavior of human mesenchymal stem cells
Kyung-Min Choi
Hee-Hoon Yoon
Young-Kwon Seo
Kye-Yong Song1
Soon-Yong Kwon2
Hwa-Sung Lee3
Yong Soon Park3
Young-Jin Kim4
Jung-Keug Park†
Department of Chemical and Biochemical Engineering, Dongguk University, Seoul 100-715, Korea 1Department of Pathology, Chung-Ang University, Seoul 156-756, Korea 2Department of Orthopedics, Catholic University, Seoul 150-713, Korea 3Department of Medical Information Engineering, Kwangju Health Collage, Kwangju 506-701, Korea 4Biomedical Research Institute, Lifecord. Ltd., Suwon 442-749, Korea
jkpark@dongguk.edu
Korean Journal of Chemical Engineering, November 2007, 24(6), 1058-1063(6)
https://doi.org/10.1007/s11814-007-0121-8
https://doi.org/10.1007/s11814-007-0121-8
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Abstract
Mesenchymal stem cells (MSCs) from bone marrow appear to be an attractive tool for use in tissue engineering and cell-based therapies due to their multipotent capacity. The majority of studies on MSCs have been restricted to the roles of growth factors, cytokines, and hormones. Based on previous reports demonstrating the important roles of amino acids, we sought to evaluate the effect of essential amino acids (EAs) and nonessential amino acids (NEAs) on the proliferation and differentiation of MSCs. The results showed that the EA/NEA compositions during culture could significantly modulate MSC proliferation and differentiation and, especially, that EAs served as a potent positive modulator in the proliferation of MSCs without causing a deficit in the differentiation capacity of the cells. These results will be very useful in the production of MSC-based cell therapy products for use in the field of tissue engineering and regenerative medicine.
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