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Received January 22, 2002
Accepted March 22, 2002
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Separation of Mixed Solutes Using Reciprocating Size Exclusion Chromatography: Computer Simulation Based upon Experimental Parameters
Department of Biological Engineering, Inha University, Incheon 402-751, Korea
Korean Journal of Chemical Engineering, July 2002, 19(4), 663-668(6), 10.1007/BF02699314
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Abstract
Mixed solutes of different molecular size were separated by reciprocating size exclusion chromatography and the results were compared with conventional size exclusion chromatography with repeated feeds using computer simulation. Operational conditions, such as overlapping between elution curves and diffusivities of solutes, were varied in simulation. Simulation showed the separation efficiency was higher in RSEC than SEC with repeated feeds in the region of high diffusivity of either solutes at low degree of overlapping. Further study to improve RSEC by employing temperature swing is being made.
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References
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Row KH, "Principle and Application of Liquid Chromatography," Inha Univ. Press, Korea (1999)
Hong SB, Row KH, Korean J. Chem. Eng., 19(2), 314 (2002)
Janson JC, Korean J. Chem. Eng., 18(2), 149 (2001)
Jonsson JA, "Chromatographic Theory and Basic Princiles," Marcel Dekker. 7. Pharmacia, "Gel Filtration: Theory and Practice," Uppsala, Sweden
Kim YM, Chang WJ, Koo YM, Prog. Biotechnol., 16, 21 (2000)
Kim YM, Chang WJ, Koo YM, Biotechnol. Tech., 13, 715 (1999)
Koo YM, "Size Exclusion Cyclic Separation," (Ph.D. Dissertation), Purdue University, U.S.A. (1985)
Riggs JB, "An Introduction to Numerical Methods for Chemical Engineers," Texas Tech University Press, U.S.A. (1995)
Row KH, "Principle and Application of Liquid Chromatography," Inha Univ. Press, Korea (1999)
