Articles & Issues
- Language
- English
- Conflict of Interest
- In relation to this article, we declare that there is no conflict of interest.
-
This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © KIChE. All rights reserved.
All issues
Single and Competitive Isotherms of Phenol and o-Cresol by Pulsed-Input Method
Center of Advanced Bioseparation Technology and Division of Chemical Engineering, Inha University, Inchon 402-751, Korea 1Environment Remediation Research Center, KIST, Seoul, Korea
rowkho@inha.ac.kr
Korean Journal of Chemical Engineering, November 2000, 17(6), 625-628(4)
https://doi.org/10.1007/BF02699107
https://doi.org/10.1007/BF02699107
Download PDF
Abstract
There is a considerable industrial interest in both the scale-up and optimization of chromatographic operations used in the purification of fine chemicals and biomolecules. One of the major factors affecting the adsorption operation is the adsorption isotherm. Reversed-phase high-performance liquid chromatography (RP-HPLC) was used to measure the adsorption isotherm of phenol and a-cresol. From the experimental results, the retention times were decreased with increasing sample sizes, and the front of the peak was very stiff, so Langmuir adsorption isotherm was applied. Also Early-eluting component, phenol, in a mixture of the two components elutes faster than that in a pure component. Pulsed-injection method (PIM) was used to determine the two parameters of the Langmuir isotherm. The resulting parameters, a and b, were used to calculate the elution profiles of phenol and o-cresol in pure and mixed state. The agreement between the experimental data and calculated elution profiles was fairly good in a mixture as well as a pure component.
References
Choi YS, Lee CH, Row KH, J. Korean Ind. Eng. Chem., 9(3), 430 (1998)
Choi YS, Lee JH, Row KH, J. Korean Ind. Eng. Chem., in press
Fritz W, Schluender EU, Chem. Eng. Sci., 29, 1279 (1974)
Guan H, Stanley BJ, Guiochon G, J. Chromatogr. B, 659, 24 (1994)
Guiochon G, Golshan-Shirazi S, Katti AM, "Fundamentals of Preparative and Nonlinear Chromatography," Academic Press, Inc. (1994)
Jacobson J, Frenz J, Horvath CS, J. Chromatogr., 316, 53 (1984)
Jacobson S, Golshan-Shirazi S, Guiochon G, AIChE J., 37, 836 (1991)
Jandera P, Komers D, J. Chromatogr. A, 762, 3 (1997)
Jandera P, Posvec Z, Vrespir P, J. Chromatogr. A, 734, 125 (1996)
Jung YA, Row KH, Korean J. Chem. Eng., 15(5), 538 (1998)
Row KH, Lee CB, Korean J. Chem. Eng., 16(1), 22 (1999)
Row KH, Lee JW, Korean J. Chem. Eng., 16(2), 170 (1999)
Choi YS, Lee JH, Row KH, J. Korean Ind. Eng. Chem., in press
Fritz W, Schluender EU, Chem. Eng. Sci., 29, 1279 (1974)
Guan H, Stanley BJ, Guiochon G, J. Chromatogr. B, 659, 24 (1994)
Guiochon G, Golshan-Shirazi S, Katti AM, "Fundamentals of Preparative and Nonlinear Chromatography," Academic Press, Inc. (1994)
Jacobson J, Frenz J, Horvath CS, J. Chromatogr., 316, 53 (1984)
Jacobson S, Golshan-Shirazi S, Guiochon G, AIChE J., 37, 836 (1991)
Jandera P, Komers D, J. Chromatogr. A, 762, 3 (1997)
Jandera P, Posvec Z, Vrespir P, J. Chromatogr. A, 734, 125 (1996)
Jung YA, Row KH, Korean J. Chem. Eng., 15(5), 538 (1998)
Row KH, Lee CB, Korean J. Chem. Eng., 16(1), 22 (1999)
Row KH, Lee JW, Korean J. Chem. Eng., 16(2), 170 (1999)
