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A MATHEMATICAL MODEL FOR THE REGULATION OF TRYPTOPHAH PROMOTER
Korean Journal of Chemical Engineering, October 1994, 11(4), 282-289(8), 10.1007/BF02697395
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Abstract
Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indoles-crylic acid(IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree behaviors agree with the previous experimental investigation.
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