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Issue
Korean Journal of Chemical Engineering,
Vol.30, No.7, 1359-1367, 2013
Viruses as self-assembled nanocontainers for encapsulation of functional cargoes
Wu Y, Yang H, Shin HJ
Viruses naturally exhibit an incredible variety of sophisticated nanostructures, which makes them ideal biological building blocks for nanoengineered material research. By mimicking their spontaneous assembly process, tremendous advances have been made towards utilizing virus and virus-like particles (VLPs) as protein cages, scaffolds, and templates for nanomaterials in the last few years. This review outlines recent progress in the field of bionanotechnology in which viruses are introduced to encapsulate various functional cargoes in a precise and controlled fashion. The encapsulation mechanisms are summarized into three main strategies: electrostatic interaction, chemical conjugation, and covalent attachment by genetic manipulation. The combination with chemical modification and genetic engineering heralds a brilliant future for fabrication of functional nanomaterials. These well-defined architectures will find attractive applications in biosensing, drug delivery, enzyme confinement, light-harvesting system, and pharmaceutical therapy.
Keywords: Virus; Virus-like Particles (VLPs); Encapsulation; Nanomaterials; Drug Delivery
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