The technology enabling the large-scale production of catalysts by extrusion is very important for the commercialization of the Fischer-Tropsch process. In this study, the influence of the binder on the extrudate of Fe-based catalyst well known as FT catalysts has been studied. Inorganic binders such as kaolin, bentonite, alumina sol and silica sol and organic binders were added during extrudate preparation. The extrudates have been prepared with various compositions, and the physicochemical properties of the extrudates have been examined by XRD, BET, PSD, TPR and UTM. The optimum binder composition of extrudate was established by comparing the FT reaction activity.