In this study, we investigated that hydrate formation and phase behavior of the THF + H2 binary clathrate hydrates. In order to confirm the binary clathrate hydrate formation we employed the Raman and NMR spectroscopies that are known to be quite powerful tools, particularly for examining the cage occupancy pattern of guest molecules. In addition, we traced the P-T profiles from clathrate hydrate formation and dissociation process, which made it possible for the resulting phase equilibrium boundary to be clearly established. In the binary clathrate hydrate matrix we further identified that the relatively large THF molecules can only occupy the large 5^(12)6^(4) cavities, while the small H2 molecules are entrapped in the empty 5^(12) cavities in structure-II, making the hydrate to be stable above 273 K even at relatively low pressure condition. Considering that pure H2 hydrate can be produced at the extreme pressures higher that 1,000 bar, we can conclude that the water-soluble second guest inclusion induces H2 storage and transportation to be readily achievable under much milder conditions.