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Issue
Korean Chemical Engineering Research,
Vol.45, No.6, 529-535, 2007
대사산물 과량생산을 위한 미생물 균주의 시스템 생물학 연구 및 대사특성 개량
Systems Biology Studies and Metabolic Modification of Metabolites Producing Bacteria
홍순호
최근 DNA microarray, 2-D gel, MS/MS 등 다양한 high-throughput 기술의 발달에 힘입어 생명체의 복잡한 대사특성을 종합적으로 분석하려는 시도가 이루어지고 있으며, 이를 시스템 생물학이라 칭하고 있다. 특히 근래에 들어 고유가 등 산업환경의 변화에 따라 미생물의 대사특성을 개량하여 다양한 화학물질들을 생물학적으로 생산하려는 연구가 최근 많은 관심을 얻고 있으며, 이를 위하여 다양한 시스템 생물학 혹은 시스템 생물공학 연구가 수행되어져 왔다. 본 총설에서는 시스템 생물공학 연구에 대한 소개 및 사용되는 여러 연구전략들을 소개하고, 이러한 시스템 생물공학 연구들이 실제 대사산물 생산균주의 개량에 어떻게 적용되었는지 살펴보고자 한다.
Recently, an attempt to analyze and modify metabolic networks of living organisms in global level emerged with the benefit of development of high-throughput techniques, and it is generally called systems biology. Various systems biology studies have been carried out for the development of enhanced metabolite production systems. By modification of metabolic characteristics of microorganisms, metabolite productivities and yields obtained with metabolically engineered bacteria increased significantly compare with that obtained with wild type bacteria.
Keywords: Systems Biology; Systems Biotechnology; Metabolic Engineering; Metabolism Modification
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