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Issue
Korean Chemical Engineering Research,
Vol.59, No.3, 455-466, 2021
Experimental Investigation on Finasteride Microparticles Formation via Gas Antisolvent Process
Najafi M, Esfandiari N, Honarvar B, Aboosadi ZA
Micro and nanoparticles of Finasteride were prepared by gas-antisolvent method. The influence of process parameters such as pressure (100, 130 and 160 bar), temperature (308, 318 and 328 K) and solute concentrations (10, 25 and 40 mg/ml) on mean particle size was studied by Box-Behnken design. As ANOVA results indicated, the highest influence in production of smaller particles was attributed to the pressure. Optimum condition leading to the smallest particle size was as follows: initial solute concentration, 10 mg/ml; temperature, 308 K and pressure, 160 bar. The particles were evaluated with FTIR, SEM, DLS, XRD as well as DSC. The analyses revealed a size decrease in the precipitated Finasteride particles (232.4 nm, on mean) via gas-antisolvent method, as compared to the original particles (55.6 μm).
Keywords: Response surface methodology; Supercritical fluid technology; Dimethyl sulfoxide; Finasteride; Nanoparticle
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