This study investigated the removal efficiency of residual pentane from paclitaxel according to the drying temperature in the case of rotary evaporation, and performed a kinetic and thermodynamic analysis of the drying process. At all the temperatures (25, 30, 35, 40, and 45 °C), a large amount of the residual solvent was initially removed during the drying, and the drying efficiency increased when increasing the drying temperature. Five drying models (Newton, Page, modified Page, Henderson and Pabis, Geometric) were then used for the kinetic analysis, where the Henderson and Pabis model showed the highest coefficient of determination (r2) and lowest root mean square deviation (RMSD), indicating that these models were the most suitable. Furthermore, in the thermodynamic analysis of the rotary evaporation, the activation energy (Ea) was 4.9815 kJ/mol and the standard Gibbs free energy change (ΔG0) was negative, whereas the standard enthalpy change (ΔH0) and standard entropy change (ΔS0) were both positive, indicating that the drying process was spontaneous, endothermic, and irreversible.