ISSN: 0304-128X ISSN: 2233-9558
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Conflict of Interest
In relation to this article, we declare that there is no conflict of interest.
Publication history
Received August 8, 2023
Revised September 26, 2023
Accepted September 26, 2023
articles This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Most Cited

Doxorubicin-loaded PEI-silica Nanoparticles for Cancer Therapy

Chung-Ang University 1PCL, Inc.
Korean Chemical Engineering Research, November 2023, 61(4), 570-575(6), 10.9713/kcer.2023.61.4.570 Epub 1 November 2023
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Targeted anticancer drug delivery systems are needed to enhance therapeutic efficacy by selectively

delivering drugs to tumor cells while minimizing off-target effects, improving treatment outcomes and reducing toxicity.

In this study, a silica-based nanocarrier capable of targeting drug delivery to cancer cells was developed. First, silica

nanoparticles were synthesized by the Stöber method using the surfactant cetyltrimethylammonium bromide (CTAB).

Increasing the ratio of EtOH in the solvent produced uniformly spherical silica nanoparticles. Washing the nanoparticles

removed unreacted residues, resulting in a non-toxic carrier for drug delivery in cells. Upon surface modification, the

pH-responsive polymer, polyethyleneimine (PEI) exhibited slow doxorubicin release at pH 7.4 and accelerated release at

pH 5.5. By exploiting this feature, we developed a system capable of targeted drug release in the acidic tumor



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