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Received February 28, 2021
Accepted May 12, 2021
Available online July 20, 2021
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This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/bync/3.0) which permits
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Experimental Investigation on Finasteride Microparticles Formation via Gas Antisolvent Process
Department of Chemical Engineering, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
esfandiari_n@miau.ac.ir
Korean Chemical Engineering Research, August 2021, 59(3), 455-466(12)
https://doi.org/10.9713/kcer.2021.59.3.455
https://doi.org/10.9713/kcer.2021.59.3.455
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Abstract
Micro and nanoparticles of Finasteride were prepared by gas-antisolvent method. The influence of process parameters such as pressure (100, 130 and 160 bar), temperature (308, 318 and 328 K) and solute concentrations (10, 25 and 40 mg/ml) on mean particle size was studied by Box-Behnken design. As ANOVA results indicated, the highest influence in production of smaller particles was attributed to the pressure. Optimum condition leading to the smallest particle size was as follows: initial solute concentration, 10 mg/ml; temperature, 308 K and pressure, 160 bar. The particles were evaluated with FTIR, SEM, DLS, XRD as well as DSC. The analyses revealed a size decrease in the precipitated Finasteride particles (232.4 nm, on mean) via gas-antisolvent method, as compared to the original particles (55.6 μm).
Keywords
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Jafari D, Nowee S, Noie S, J. Dispersion Sci. Technol., 38(5), 677 (2017)
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Ardestani NS, Sodeifian G, Sajadian SA, Heliyon, 6(9), e04947 (2020)
